Melav2, an elav-like gene, is essential for spermatid differentiation in the flatworm Macrostomum lignano
نویسندگان
چکیده
منابع مشابه
Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.
The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity. Following injury, it can regenerate almost an entirely new organism because of the presence of an abundant somatic stem cell population, the neoblasts. This set of unique properties makes many flatworms attractive organisms for studying the evolution of pathways involved in tissue self-renewal, cell-fate spec...
متن کاملThe Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research
Bioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. Some ion channels are directly implemented in chemical signaling pathways, the others are involved in regulation of cytoplasmic or vesicular ion concentrations, pH, cell volume, and membrane potentials. Together with ion transporters and gap junction complexes,...
متن کاملA novel flatworm-specific gene family implicated in reproduction in Macrostomum lignano
Free-living flatworms, such as the planarian Schmidtea mediterranea, are extensively used as model organisms to study stem cells and regeneration. The majority of studies in planarians so far focused on broadly conserved genes. However, investigating what makes these animals different might be equally informative for understanding its biology. Here, we present a re-analysis of neoblast and germ...
متن کاملBoule-like genes regulate male and female gametogenesis in the flatworm Macrostomum lignano
Members of the DAZ (Deleted in AZoospermia) gene family are important players in the process of gametogenesis and their dysregulation accounts for 10% of human male infertility. Boule, the ancestor of the family, is mainly involved in male meiosis in most organisms. With the exception of Drosophila and C. elegans, nothing is known on the function of boule in non-vertebrate animals. In the prese...
متن کاملThe Hippo pathway regulates stem cells during homeostasis and regeneration of the flatworm Macrostomum lignano.
The Hippo pathway orchestrates activity of stem cells during development and tissue regeneration and is crucial for controlling organ size. However, roles of the Hippo pathway in highly regenerative organisms, such as flatworms, are unknown. Here we show that knockdown of the Hippo pathway core genes in the flatworm Macrostomum lignano affects tissue homeostasis and causes formation of outgrowt...
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ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2009
ISSN: 1471-213X
DOI: 10.1186/1471-213x-9-62